Are you opening the SAME file (IE off a USB drive or the web)? Or are you working with two different local copies, one on each machine? If it is the latter, well, the copy on your home 'puter may be damaged, pure and simple, make a copy from your work PC and transfer to home.
If that isn't the problem, I'd make sure you are running the same reader software and version (Both Adobe Reader 9.0, for instance, Not one FoxIt and one Adobe) and if you are say, opening it with the full Acrobat, that could make a difference.