According to the CDC is 8 drinks in a week for a female and 15 drinks in a week for a male.
http://www.cnn.com/2014/06/26/health/heavy-drinking-definition/index.html
One in 10 deaths among adults between the ages of 20 and 64 are due to excessive alcohol consumption, the CDC says in a report released Wednesday. That means some 88,000 people die a year as a result of drinking too much. The majority of those are men -- about 70%.
http://www.cnn.com/2014/06/26/health/heavy-drinking-definition/index.html