We analyzed BT data in the de-identified database of COVID-19-suspected patients in Mount Sinai and its affiliated hospitals in the New York area as of May 3, 2020. A total of 9417 patients tested positive for the SARS-CoV-2 virus by RT-PCR detection. After excluding patients with missing temperature data (
n = 1802), 7614 patients were included in the analysis (Table
1). Fifty percent had a BT > 37 °C on the initial presentation and 78.5% of patients developed BT > 37 °C during the course of the disease. The overall mortality was 16.9% with a median of 7 days to death from the initial presentation. As shown in Fig.
1a, higher BT at the initial presentation did not show a significant association to mortality. Importantly, patients presenting with BT ≤ 36 °C had the highest mortality (26.5%,
P = 0.003 relative to 36 °C < BT ≤ 37 °C), and this became even higher when the analysis was restricted to those with BT ≤ 35.5 °C (44%), indicating low body temperature at the initial presentation is a marker of poor prognosis. Meanwhile, maximum BT during COVID-19 infection was significantly correlated with mortality rate (Fig.
1b). There was a significant increase in mortality for every 0.5 °C increase in BT, and the mortality was as high as 42% in those with maximum BT > 40.0 °C
.