YES
I have only ever had it done once and am never allowed to have it done again.
The asked all the normal questions are you allergic to shellfish, etc, etc.
The minute they put the needle in my arm I felt like someone had poured gasoline through every vein in my body and struck a match, I explained this to the doctor and he said he had never heard of it before. Then asked if I thought I could proceed, I told him might as well it's already in my system. The doc said if you have any problems just raise your hand and I'll stop testing and come get you. He close the door I layed down flat and before I could fully extend my arm up I was voilently get sick all over myself.
Not fun at all..
To this day the know something in it I am allergic to, to have that kinda reaction but don't know what...