What about the "stepping stone (unintended humor) argument?" You know, "using marijuana can lead to other, more dangerous drugs." Do we counter that argument by legalizing all drugs? Where should it stop, Cocaine, Heroin? I don't think it will ever be legal if it's not by now. Think about it, most of Congress and the growing voting majority, "baby boomers," were teenagers or older during the heyday of pot smoking. There doesn't seem to be an outcry of support for legalization to the extent that you would think by those who were directly affected in one way or another by the cultural "revolution" of the sixties and seventies that greatly influenced the tolerance toward pot and other drugs.
Having said that, I still think its a matter of control. Most folks can't manufacture their own liquor; any clown with a grow light, seeds and little fertilizer can grow pot. The $100 granny spends on her pot could be invested in your own personal pot farm thereby cutting out the government. You know that will never fly. Even if "seedless" marijuana was sold you'd just create a black market for seeds.