Interesting comments made on this post. Its funny to read the same old arguments...especially the "knock down power" of the 45.
Home defense - if you can't hit what your aiming at...whats the point? Size, recoil control, sights, etc etc go a long way.
Do yourself a favor, attend an organized shoot. A Sanners Lake IDPA event is a good start. There you will find a handfull of individuals more than willing to let you handle and fire their guns. Only you will know what feels right and what doesn't. Trust me, my wife and I have tried/owned them all. She found the Glock works for her only by trying what I just mentioned. Besides, this approach is easier on the pocket book.
I would also stress a shooting course or participation in an organized event such as IDPA or USPSA. (I would suggest IDPA first if this is your first time as it is more regimented...and less "running and gunning")
I can swear to you, my wife and I gun awareness increased 100 times over by shooting in these events. Other that an LE professional that handles a firearm on a daily basis, the normal everyday citizen does not have an opportunity to become familiar enough with their weapon. Shooting is half the battle. Clearing malfunctions, shooting from odd positions, reloads, etc is what seperates a casual shooter from a seasoned shooter.
In short I would pitty the person that attempted to break into our house now. Not meant as a joke or bragging, it is a fact. No night sights or lasers needed, our experience and gun skills have increased to a point that our shots will go where intended.
This got way longer than I planned. If you want to PM me feel free. If I don't own what you want to try chances are I know someone who does.
As mentioned earlier, this is serious stuff. You need to be informed and prepared.